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Deficiencies in vitamin B12 can lead to symptoms like headaches, fatigue, irritability, depression, anxiety, numbness and tingling in extremities, digestive problems and even nerve damage and cognitive issues

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For individuals with atrophic gastritis, pernicious anaemia, or those taking proton pump inhibitors , food-bound B12 absorption is already compromised

The practical implication for researchers is that tirzepatide protocols often produce more pronounced metabolic effects than equivalent semaglutide protocols, which the semaglutide versus tirzepatide comparison documents in detail